The effective navigation of healthcare systems, the comprehension of medical information, and the active participation in one’s care require health literacy and patient empowerment. However, much of the health-related content provided to patients—whether through healthcare apps, informational leaflets, or online resources—remains inaccessible, overly complex, and detached from the unique needs of diverse individuals. Addressing this challenge, our research integrates health psychology, cognitive sciences, and advanced AI technologies to create HEALIE (HEALth Information Enhancement). Healie is an innovative system designed to transform the way personalized medical information is delivered.